oralbioavailability相关论文
Probing the new strategy for the oral formulations of taxanes:changing the method with the situation
The first-generation taxanes(including paclitaxel and docetaxel)are widely used for the treatment of various cancers in ......
A lipophilic prodrug of Danshensu: preparation, characterization, and in vitro and in vivo evaluatio
Danshensu [3-(3,4-dihydroxyphenyl) lactic acid,DSS],one of the significant cardioprotective components,is extracted from......
Self-assembled micelles for enhancing the oral bioavailability of 9-nitrocamptothecin via Soluplus(R
Our study aimed to develop an amorphous 9-nitrocamptothecin solid dispersion(9-NC-SD)using polyvinyl caprolactam-polyvin......
In vitro and in vivo performance of nanocrystals: a comparison of rod shaped nanocrystals and spheri
The objective of this study was to compare the in vitro and in vivo performance of rod shaped and spherical like nanocry......
Solid dispersion technology has been widely applied to improve the solubility and dissolution rate of poorly water-solub......
Enhancing oral bioavailability of mangiferin in rats by preparing phospholipid complex and lipid-bas
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The in vitro and in vivo study of the 12-3-12 cationic Gemini surfactant as a novel gastrointestinal
To improve the oral bioavailability of nanocrystalline drug preparations, the cationic 12-3-12 quaternary ammonium surfa......
Comparison alone or combined with P-gp inhibitors on syringaresinol absorption using single-pass int
This work determined the mechanisms of enhancing the oral bioavailability of syringaresinol (SG).The in situ perfusion m......
The phospholipid-bile salts-mixed micelles (PL-BS-MMs) are potent carriers used for oral absorption of drugs that are po......
Poly(ADP-ribose)polymerase-1(PARP-1)is a nuclear enzyme involved in the detection and repair of DNA damage.The inhibitio......
Intestinal OCTN2 transporter as a target for enhanced oral delivery for small-molecule prodrug and L
The organic cation/camitine transporter (OCTN2) is a high affinity cation/carnitine transporter widely expressed in huma......
Enhanced dissolution and oral bioavailability of aripiprazole nanosuspensions prepared by nanoprecip
Reducing the particle size of drugs to produce nanosuspensions or nanocrystals,is quite advantageous for poorly soluble ......
A novel oral preparation of hydroxysafflor yellow A base on a chitosan complex a strategy to enhance
Hydroxysafflor yellow A (HSYA), the main active pharmaceutical ingredient of the safflower plant (Carthamus tinctori......
